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General Information
| Full Name | Masoud Khani |
| khanim@uwm.edu | |
| linkedin.com/in/masoudmk | |
| Location | Milwaukee, WI |
Summary
| Profile | Computational scientist specializing in medical modeling, simulation, and AI for healthcare applications. Expertise in developing hybrid simulation-ML frameworks, patient-specific digital twins, and explainable AI systems for clinical decision support. Research combines agent-based modeling, discrete-event simulation, transformer architectures, and large language models to address challenges in disease trajectory prediction, risk stratification, and intervention evaluation. |
Research Interests
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Medical Modeling & Simulation
- Agent-based models, discrete-event simulation, hybrid ML-simulation approaches for clinical decision support, intervention evaluation frameworks, and health system optimization
- Developing computational frameworks that integrate real-world data for population health applications
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Digital Twins for Healthcare
- Patient-specific modeling for personalized medicine, real-time risk stratification using multimodal data (EHR, sensors, imaging)
- Uncertainty quantification in clinical predictions and dynamic 'what-if' scenario analysis for intervention planning
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Large Language Models in Medicine
- Clinical text understanding, medical question answering, synthetic data generation, retrieval-augmented generation for evidence-based practice
- LLM-enhanced clinical education and simulation platforms, comprehensive safety evaluation frameworks
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Responsible AI for Healthcare
- Explainability methods (SHAP, LIME, attention mechanisms), fairness assessment across demographics, algorithmic bias mitigation
- Uncertainty quantification and stakeholder-centered design with patient and clinician engagement
Education
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Sep. 2021 – Present (Expected Aug. 2026)
Ph.D., Biomedical and Health Informatics
University of Wisconsin–Milwaukee, Milwaukee, WI
- Dissertation: Medical modeling, simulation, and AI for clinical decision support
- Focus: Agent-based models, discrete-event simulation, transformer-based disease trajectory modeling, LLMs in medicine, and explainable AI for healthcare
- GPA: 3.8/4.0
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Jan. 2020 – Aug. 2021
M.S., Computer Science
University of Wisconsin–Milwaukee, Milwaukee, WI
- Thesis: Medical Image Segmentation Using Machine Learning (deep learning for wound image segmentation)
- GPA: 3.7/4.0
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Sep. 2014 – Jun. 2018
B.S., Software Engineering
Tehran Azad University, Tehran, Iran
- Thesis: Fall Detection in the Elderly Using Smartphones via Machine Learning Techniques
- GPA: 3.5/4.0
Professional & Research Experience
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Jun. 2025 – Present
Engineer I
Medical College of Wisconsin — ReyLab (Neurosurgery Research), Milwaukee, WI
- Investigate mechanisms of human episodic memory formation and retrieval by developing data acquisition systems that integrate multiscale neural recordings (MRI, intracranial EEG, microwire single-unit/LFP) with cognitive task paradigms in epilepsy patients
- Advance epilepsy diagnosis and treatment through engineering of real-time analysis pipelines for seizure onset zone localization, leveraging single-neuron firing patterns and local field potential biomarkers
- Lead development of MCWs (MiCroWire sorter), a modular, open-source spike sorting framework engineered for human intracerebral recordings in clinical settings (first co-author, bioRxiv preprint)
- Build reproducible computational infrastructure for large-scale neural data analysis (40-core systems, 250TB storage), implementing automated quality control, artifact rejection, and feature extraction workflows
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Sep. 2021 – Sep. 2025
Research Assistant
University of Wisconsin–Milwaukee — Biomedical Data and Language Processing Lab, Milwaukee, WI
- Develop AI-driven clinical decision support systems for NIH-funded research, integrating agent-based modeling, discrete-event simulation, and machine learning to evaluate population health interventions
- Build LLM-based agentic systems for clinical applications using transformer architectures, synthetic data generation, RAG, and prompt engineering
- Design explainable AI frameworks combining SHAP analysis, attention mechanisms, and natural language generation to translate complex temporal prediction models into clinically interpretable risk pathways
- Engineer scalable data processing infrastructure for large-scale health datasets (7M+ patients) using distributed computing frameworks
- Collaborate across clinical specialties (otolaryngology, cardiology, gastroenterology, neurosurgery, geriatrics), contributing to 20+ publications
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Jun. 2023 – Aug. 2023
Data Scientist Intern
Medical College of Wisconsin — Clinical and Translational Science Institute, Milwaukee, WI
- Reimplemented WaveClus3 spike-sorting algorithm from MATLAB to Python, optimizing computational efficiency for large-scale human intracranial recordings from epilepsy patients
- Designed novel artifact rejection methods to improve single-neuron detection in hospital-based electrophysiology environments
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Jan. 2021 – May 2023
Project Assistant
University of Wisconsin–Milwaukee — Northwestern Mutual Data Science Institute, Milwaukee, WI
- Conducted data-driven program evaluation studies analyzing enrollment patterns, learning outcomes, and engagement metrics for interdisciplinary data science curricula
- Built open-source educational framework with 50+ reproducible data science examples demonstrating real-world applications of statistical modeling and machine learning
Teaching & Mentoring
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Sep. 2024 – Dec. 2025
Lecturer
University of Wisconsin–Milwaukee — College of Health Sciences, Milwaukee, WI
- Big Data & Healthcare Informatics (Graduate): Designed and delivered comprehensive curriculum covering distributed computing frameworks (Apache Spark), machine learning for large-scale health data, deep learning architectures, and production AI systems for 60+ graduate students
- Introduction to Healthcare Informatics (Graduate): Taught foundational course spanning health IT ecosystems, stakeholder analysis, clinical decision support systems, medical image processing, AI/ML in healthcare, data standards (HL7, FHIR), and translational informatics
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Aug. 2023 – Sep. 2024
Teaching Assistant
University of Wisconsin–Milwaukee — Big Data & Healthcare Informatics, Milwaukee, WI
- Led lab sessions on applied healthcare data science, teaching graduate students to implement ML pipelines, develop simulation models, and analyze EHRs using Python-based frameworks
- Contributed to curriculum development by designing assignments, creating coding tutorials, and developing assessment rubrics
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Ongoing
Research Mentorship
University of Wisconsin–Milwaukee
- Mentored 10+ undergraduate and graduate students on research projects involving medical modeling, machine learning, and clinical data analysis
- Supervised 5+ students through completion of thesis projects
Research Funding & Awards
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2021–Present
- NIH-funded Research (Team Member): Advancing Healthier Wisconsin Endowment — AI-driven clinical decision support systems for otolaryngology and geriatric care
- CTSI Pilot-BERD Methodological Innovation — Advanced explainable AI methodologies for clinical prediction models
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2024–2025
- NMDSI Student Scholars Award — $7,500 (Northwestern Mutual Data Science Institute). Funded LLM-based clinical applications research
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2024
- Chancellor's Graduate Student Award — $2,500 (Apr. 2024)
- Chancellor's Graduate Student Award — (Fall 2024)
- Graduate Student Travel Award — $1,500 (May 2024). Conference presentations on pancreatic cancer mortality
- Best Reviewer Award — AMIA Informatics Summit, 2024
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2020
- Chancellor's Graduate Student Award — $6,000 (Jan. 2020)
Technical Skills
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Medical Modeling & Simulation
- Agent-Based Modeling (ABM)
- Discrete-Event Simulation (DES)
- System Dynamics
- Monte Carlo Simulation
- Digital Twin Development
- Stochastic Modeling
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Machine Learning & Deep Learning
- PyTorch
- TensorFlow
- scikit-learn
- Hugging Face Transformers
- XGBoost
- LightGBM
- Reinforcement Learning
- Federated Learning
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Large Language Models
- Hugging Face Ecosystem
- OpenAI API
- NVIDIA NeMo
- LangChain
- Fine-tuning (LoRA, QLoRA)
- Retrieval-Augmented Generation (RAG)
- Prompt Engineering
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Explainable AI
- SHAP
- LIME
- Attention Visualization
- Integrated Gradients
- Counterfactual Explanations
- Uncertainty Quantification
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High-Performance Computing
- Apache Spark
- Dask
- RAPIDS
- Ray
- Distributed Training
- HPC Cluster Management
- Cloud Platforms (AWS, GCP, Azure)
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Programming & Development
- Python (Expert)
- R
- SQL
- MATLAB
- Git/GitHub
- Docker
- Jupyter
- Linux/Unix
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Data Engineering
- MySQL
- PostgreSQL
- MongoDB
- ETL Pipelines
- Data Preprocessing
- Feature Engineering
Scholarly Service & Leadership
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Peer Review Service
- Nature Communications
- JAMA Network Open
- Applied Clinical Informatics
- Journal of Medical Internet Research (JMIR) family (Public Health and Surveillance, JMIRx Med, JMIR AI)
- AMIA Annual Symposium and Informatics Summit (2023–Present)
- APHA Annual Meeting
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Multi-institutional Collaboration
- Columbia University
- University of Florida
- University of Tehran
- Multiple medical centers (data sharing and methodological consultation)
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Research Mentorship
- Mentored 10+ undergraduate and graduate students on research projects
- Supervised 5+ students through completion of thesis projects
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Professional Memberships
- American Medical Informatics Association (AMIA)
- American Public Health Association (APHA)