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General Information

Full Name Masoud Khani
Email khanim@uwm.edu
LinkedIn linkedin.com/in/masoudmk
Location Milwaukee, WI

Summary

Profile Computational scientist specializing in medical modeling, simulation, and AI for healthcare applications. Expertise in developing hybrid simulation-ML frameworks, patient-specific digital twins, and explainable AI systems for clinical decision support. Research combines agent-based modeling, discrete-event simulation, transformer architectures, and large language models to address challenges in disease trajectory prediction, risk stratification, and intervention evaluation.

Research Interests

  • Medical Modeling & Simulation
    • Agent-based models, discrete-event simulation, hybrid ML-simulation approaches for clinical decision support, intervention evaluation frameworks, and health system optimization
    • Developing computational frameworks that integrate real-world data for population health applications
  • Digital Twins for Healthcare
    • Patient-specific modeling for personalized medicine, real-time risk stratification using multimodal data (EHR, sensors, imaging)
    • Uncertainty quantification in clinical predictions and dynamic 'what-if' scenario analysis for intervention planning
  • Large Language Models in Medicine
    • Clinical text understanding, medical question answering, synthetic data generation, retrieval-augmented generation for evidence-based practice
    • LLM-enhanced clinical education and simulation platforms, comprehensive safety evaluation frameworks
  • Responsible AI for Healthcare
    • Explainability methods (SHAP, LIME, attention mechanisms), fairness assessment across demographics, algorithmic bias mitigation
    • Uncertainty quantification and stakeholder-centered design with patient and clinician engagement

Education

  • Sep. 2021 – Present (Expected Aug. 2026)
    Ph.D., Biomedical and Health Informatics
    University of Wisconsin–Milwaukee, Milwaukee, WI
    • Dissertation: Medical modeling, simulation, and AI for clinical decision support
    • Focus: Agent-based models, discrete-event simulation, transformer-based disease trajectory modeling, LLMs in medicine, and explainable AI for healthcare
    • GPA: 3.8/4.0
  • Jan. 2020 – Aug. 2021
    M.S., Computer Science
    University of Wisconsin–Milwaukee, Milwaukee, WI
    • Thesis: Medical Image Segmentation Using Machine Learning (deep learning for wound image segmentation)
    • GPA: 3.7/4.0
  • Sep. 2014 – Jun. 2018
    B.S., Software Engineering
    Tehran Azad University, Tehran, Iran
    • Thesis: Fall Detection in the Elderly Using Smartphones via Machine Learning Techniques
    • GPA: 3.5/4.0

Professional & Research Experience

  • Jun. 2025 – Present
    Engineer I
    Medical College of Wisconsin — ReyLab (Neurosurgery Research), Milwaukee, WI
    • Investigate mechanisms of human episodic memory formation and retrieval by developing data acquisition systems that integrate multiscale neural recordings (MRI, intracranial EEG, microwire single-unit/LFP) with cognitive task paradigms in epilepsy patients
    • Advance epilepsy diagnosis and treatment through engineering of real-time analysis pipelines for seizure onset zone localization, leveraging single-neuron firing patterns and local field potential biomarkers
    • Lead development of MCWs (MiCroWire sorter), a modular, open-source spike sorting framework engineered for human intracerebral recordings in clinical settings (first co-author, bioRxiv preprint)
    • Build reproducible computational infrastructure for large-scale neural data analysis (40-core systems, 250TB storage), implementing automated quality control, artifact rejection, and feature extraction workflows
  • Sep. 2021 – Sep. 2025
    Research Assistant
    University of Wisconsin–Milwaukee — Biomedical Data and Language Processing Lab, Milwaukee, WI
    • Develop AI-driven clinical decision support systems for NIH-funded research, integrating agent-based modeling, discrete-event simulation, and machine learning to evaluate population health interventions
    • Build LLM-based agentic systems for clinical applications using transformer architectures, synthetic data generation, RAG, and prompt engineering
    • Design explainable AI frameworks combining SHAP analysis, attention mechanisms, and natural language generation to translate complex temporal prediction models into clinically interpretable risk pathways
    • Engineer scalable data processing infrastructure for large-scale health datasets (7M+ patients) using distributed computing frameworks
    • Collaborate across clinical specialties (otolaryngology, cardiology, gastroenterology, neurosurgery, geriatrics), contributing to 20+ publications
  • Jun. 2023 – Aug. 2023
    Data Scientist Intern
    Medical College of Wisconsin — Clinical and Translational Science Institute, Milwaukee, WI
    • Reimplemented WaveClus3 spike-sorting algorithm from MATLAB to Python, optimizing computational efficiency for large-scale human intracranial recordings from epilepsy patients
    • Designed novel artifact rejection methods to improve single-neuron detection in hospital-based electrophysiology environments
  • Jan. 2021 – May 2023
    Project Assistant
    University of Wisconsin–Milwaukee — Northwestern Mutual Data Science Institute, Milwaukee, WI
    • Conducted data-driven program evaluation studies analyzing enrollment patterns, learning outcomes, and engagement metrics for interdisciplinary data science curricula
    • Built open-source educational framework with 50+ reproducible data science examples demonstrating real-world applications of statistical modeling and machine learning

Teaching & Mentoring

  • Sep. 2024 – Dec. 2025
    Lecturer
    University of Wisconsin–Milwaukee — College of Health Sciences, Milwaukee, WI
    • Big Data & Healthcare Informatics (Graduate): Designed and delivered comprehensive curriculum covering distributed computing frameworks (Apache Spark), machine learning for large-scale health data, deep learning architectures, and production AI systems for 60+ graduate students
    • Introduction to Healthcare Informatics (Graduate): Taught foundational course spanning health IT ecosystems, stakeholder analysis, clinical decision support systems, medical image processing, AI/ML in healthcare, data standards (HL7, FHIR), and translational informatics
  • Aug. 2023 – Sep. 2024
    Teaching Assistant
    University of Wisconsin–Milwaukee — Big Data & Healthcare Informatics, Milwaukee, WI
    • Led lab sessions on applied healthcare data science, teaching graduate students to implement ML pipelines, develop simulation models, and analyze EHRs using Python-based frameworks
    • Contributed to curriculum development by designing assignments, creating coding tutorials, and developing assessment rubrics
  • Ongoing
    Research Mentorship
    University of Wisconsin–Milwaukee
    • Mentored 10+ undergraduate and graduate students on research projects involving medical modeling, machine learning, and clinical data analysis
    • Supervised 5+ students through completion of thesis projects

Research Funding & Awards

  • 2021–Present
    • NIH-funded Research (Team Member): Advancing Healthier Wisconsin Endowment — AI-driven clinical decision support systems for otolaryngology and geriatric care
    • CTSI Pilot-BERD Methodological Innovation — Advanced explainable AI methodologies for clinical prediction models
  • 2024–2025
    • NMDSI Student Scholars Award — $7,500 (Northwestern Mutual Data Science Institute). Funded LLM-based clinical applications research
  • 2024
    • Chancellor's Graduate Student Award — $2,500 (Apr. 2024)
    • Chancellor's Graduate Student Award — (Fall 2024)
    • Graduate Student Travel Award — $1,500 (May 2024). Conference presentations on pancreatic cancer mortality
    • Best Reviewer Award — AMIA Informatics Summit, 2024
  • 2020
    • Chancellor's Graduate Student Award — $6,000 (Jan. 2020)

Technical Skills

  • Medical Modeling & Simulation
    • Agent-Based Modeling (ABM)
    • Discrete-Event Simulation (DES)
    • System Dynamics
    • Monte Carlo Simulation
    • Digital Twin Development
    • Stochastic Modeling
  • Machine Learning & Deep Learning
    • PyTorch
    • TensorFlow
    • scikit-learn
    • Hugging Face Transformers
    • XGBoost
    • LightGBM
    • Reinforcement Learning
    • Federated Learning
  • Large Language Models
    • Hugging Face Ecosystem
    • OpenAI API
    • NVIDIA NeMo
    • LangChain
    • Fine-tuning (LoRA, QLoRA)
    • Retrieval-Augmented Generation (RAG)
    • Prompt Engineering
  • Explainable AI
    • SHAP
    • LIME
    • Attention Visualization
    • Integrated Gradients
    • Counterfactual Explanations
    • Uncertainty Quantification
  • High-Performance Computing
    • Apache Spark
    • Dask
    • RAPIDS
    • Ray
    • Distributed Training
    • HPC Cluster Management
    • Cloud Platforms (AWS, GCP, Azure)
  • Programming & Development
    • Python (Expert)
    • R
    • SQL
    • MATLAB
    • Git/GitHub
    • Docker
    • Jupyter
    • Linux/Unix
  • Data Engineering
    • MySQL
    • PostgreSQL
    • MongoDB
    • ETL Pipelines
    • Data Preprocessing
    • Feature Engineering

Scholarly Service & Leadership

  • Peer Review Service
    • Nature Communications
    • JAMA Network Open
    • Applied Clinical Informatics
    • Journal of Medical Internet Research (JMIR) family (Public Health and Surveillance, JMIRx Med, JMIR AI)
    • AMIA Annual Symposium and Informatics Summit (2023–Present)
    • APHA Annual Meeting
  • Multi-institutional Collaboration
    • Columbia University
    • University of Florida
    • University of Tehran
    • Multiple medical centers (data sharing and methodological consultation)
  • Research Mentorship
    • Mentored 10+ undergraduate and graduate students on research projects
    • Supervised 5+ students through completion of thesis projects
  • Professional Memberships
    • American Medical Informatics Association (AMIA)
    • American Public Health Association (APHA)